Folding simulation of amyloid β-peptide in alzheimer's disease.

• Main Author: Koh, Jessica Li Jian.
• Other Authors: School of Physical and Mathematical Sciences
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Chemistry::Biochemistry
• Online Access: http://hdl.handle.net/10356/39874
• Institution: Nanyang Technological University

An amyloid β-peptide (Aβ) containing 42 residues is a major component of neurotic plaques in Alzheimer’s disease. The conformation of residues 1-28 of the peptide sequence determine whether the amyloid β-peptide will form neurotic aggregates, since the rest of the residues remain in β-sheet conforma...