Synthesis of furanose incorporated n-heterocyclic carbenes.

Synthesis of furanose incorporated n-heterocyclic carbenes.

Recent applications of chiral N-Heterocyclic Carbenes (NHCs) in asymmetric reactions have shown significant improvements in regio- and stereo-selectivities in metal catalyzed reactions. Utilizing carbohydrates as a readily available source of stereocentres and tunable steric bulk, a total of one mon...

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Bibliographic Details
Main Author: Chua, Chun Kiang.
Other Authors: Liu Xuewei
Format: Final Year Project
Language:English
Published: 2010
Subjects:
DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds
Online Access:http://hdl.handle.net/10356/39895
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Institution: Nanyang Technological University
Language: English
Description
Summary:Recent applications of chiral N-Heterocyclic Carbenes (NHCs) in asymmetric reactions have shown significant improvements in regio- and stereo-selectivities in metal catalyzed reactions. Utilizing carbohydrates as a readily available source of stereocentres and tunable steric bulk, a total of one mono-furanose and two di-furanose incorporated NHCs have been proposed and synthesized. With the successful synthesis of these NHCs, we hope to obtain the corresponding transition-metal complexes and subject them as catalysts to induce better regio- and stereo-selectivities in asymmetric reactions.

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