Drug delivery to bone using phosphonate as the bone-targeting substance

This report presents a study on the use of phosphonates, as the bone-targeting substance in drug delivery systems. The purpose is to do a surface modification of calcium phosphate-based drug carriers with the bone targeting substance, forming a targeted drug delivery system. In this study, monophosp...

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Main Author: Tang, Kang Min.
Other Authors: Loo Say Chye Joachim
Format: Final Year Project
Language:English
Published: 2010
Subjects:
Online Access:http://hdl.handle.net/10356/40425
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-404252023-03-04T15:31:49Z Drug delivery to bone using phosphonate as the bone-targeting substance Tang, Kang Min. Loo Say Chye Joachim School of Materials Science and Engineering DRNTU::Engineering::Materials::Biomaterials This report presents a study on the use of phosphonates, as the bone-targeting substance in drug delivery systems. The purpose is to do a surface modification of calcium phosphate-based drug carriers with the bone targeting substance, forming a targeted drug delivery system. In this study, monophosphonates were used for the synthesis of this system. This was done by attaching the phosphonate end of amino phosphonates to hydroxyapatite, in replacement of calcium phosphate on the drug carrier. Carboxyl phosphonates are then attached to the amino phosphonates via the peptide bond, hence forming the targeted drug delivery system. Affinity to hydroxyapatite of the bone-targeting compound has been tested and proven through the use of FTIR spectroscopy as well as the Nanosizer. Characterization using FTIR showed that the amino phosphonate had successfully binded to hydroxyapatite. Results from the nanosizer also showed that a stable colloidal system was formed by hydroxyapatite and amino phosphonate. In addition, the formation of the peptide bond was also observed using FTIR with the peaks belonging to the peptide bond present. This design of a targeted drug delivery system can thus be used for active targeting of drugs from the carrier directly to bones. This study suggests that other classes of phosphonates, such as bisphosphonates that display increased affinity to bones can be also be used in a similar manner in the drug delivery system. Bachelor of Engineering (Materials Engineering) 2010-06-15T08:05:11Z 2010-06-15T08:05:11Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/40425 en Nanyang Technological University 52 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering::Materials::Biomaterials
spellingShingle DRNTU::Engineering::Materials::Biomaterials
Tang, Kang Min.
Drug delivery to bone using phosphonate as the bone-targeting substance
description This report presents a study on the use of phosphonates, as the bone-targeting substance in drug delivery systems. The purpose is to do a surface modification of calcium phosphate-based drug carriers with the bone targeting substance, forming a targeted drug delivery system. In this study, monophosphonates were used for the synthesis of this system. This was done by attaching the phosphonate end of amino phosphonates to hydroxyapatite, in replacement of calcium phosphate on the drug carrier. Carboxyl phosphonates are then attached to the amino phosphonates via the peptide bond, hence forming the targeted drug delivery system. Affinity to hydroxyapatite of the bone-targeting compound has been tested and proven through the use of FTIR spectroscopy as well as the Nanosizer. Characterization using FTIR showed that the amino phosphonate had successfully binded to hydroxyapatite. Results from the nanosizer also showed that a stable colloidal system was formed by hydroxyapatite and amino phosphonate. In addition, the formation of the peptide bond was also observed using FTIR with the peaks belonging to the peptide bond present. This design of a targeted drug delivery system can thus be used for active targeting of drugs from the carrier directly to bones. This study suggests that other classes of phosphonates, such as bisphosphonates that display increased affinity to bones can be also be used in a similar manner in the drug delivery system.
author2 Loo Say Chye Joachim
author_facet Loo Say Chye Joachim
Tang, Kang Min.
format Final Year Project
author Tang, Kang Min.
author_sort Tang, Kang Min.
title Drug delivery to bone using phosphonate as the bone-targeting substance
title_short Drug delivery to bone using phosphonate as the bone-targeting substance
title_full Drug delivery to bone using phosphonate as the bone-targeting substance
title_fullStr Drug delivery to bone using phosphonate as the bone-targeting substance
title_full_unstemmed Drug delivery to bone using phosphonate as the bone-targeting substance
title_sort drug delivery to bone using phosphonate as the bone-targeting substance
publishDate 2010
url http://hdl.handle.net/10356/40425
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