Pharmaceutical powder production by spray-freeze-drying technique : design and optimization of experimental parameters.

Spray-freeze-drying (SFD) has emerged in the last decade as a manufacturing technique for proteins and other heat-sensitive compounds. However, its application to nano-medicines has not been explored. Hence, the purpose of this project is to develop and optimize the SFD conditions for the production...

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Main Author: Ng, Mabel Li Ling.
Other Authors: Kunn Hadinoto Ong
Format: Final Year Project
Language:English
Published: 2010
Subjects:
Online Access:http://hdl.handle.net/10356/40640
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-406402023-03-03T15:35:13Z Pharmaceutical powder production by spray-freeze-drying technique : design and optimization of experimental parameters. Ng, Mabel Li Ling. Kunn Hadinoto Ong School of Chemical and Biomedical Engineering DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology Spray-freeze-drying (SFD) has emerged in the last decade as a manufacturing technique for proteins and other heat-sensitive compounds. However, its application to nano-medicines has not been explored. Hence, the purpose of this project is to develop and optimize the SFD conditions for the production of nano-aggregates. In the preliminary SFD experiments conducted using silica nanoparticles (NPs), experimental parameters such as the concentration of the feed, type of exicipients used, feed and air flow rates were varied systematically to observe their influence on the particle characteristics. The findings from this study agreed well with previous SFD experiments that used protein solutions. Following that, a variety of excipients were tested to be included in the nanoparticulate feed suspension. The results of mannitol as an excipient for the SFD nano-aggregates are promising, as the particles exhibit improvements in aerosolization properties. PVA displayed potential in its unique particle morphology, which may have benefits in the re-dispersibility of the nano-aggregates in aqueous media. With the advantages of SFD and nanoparticulate technology, further tests can be carried out to optimize the aerosolization efficiency and re-dispersibility of the nano-aggregates for effective pulmonary drug delivery. Bachelor of Engineering (Chemical and Biomolecular Engineering) 2010-06-17T04:26:35Z 2010-06-17T04:26:35Z 2010 2010 Final Year Project (FYP) http://hdl.handle.net/10356/40640 en Nanyang Technological University 55 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology
spellingShingle DRNTU::Science::Medicine::Pharmacy::Pharmaceutical technology
Ng, Mabel Li Ling.
Pharmaceutical powder production by spray-freeze-drying technique : design and optimization of experimental parameters.
description Spray-freeze-drying (SFD) has emerged in the last decade as a manufacturing technique for proteins and other heat-sensitive compounds. However, its application to nano-medicines has not been explored. Hence, the purpose of this project is to develop and optimize the SFD conditions for the production of nano-aggregates. In the preliminary SFD experiments conducted using silica nanoparticles (NPs), experimental parameters such as the concentration of the feed, type of exicipients used, feed and air flow rates were varied systematically to observe their influence on the particle characteristics. The findings from this study agreed well with previous SFD experiments that used protein solutions. Following that, a variety of excipients were tested to be included in the nanoparticulate feed suspension. The results of mannitol as an excipient for the SFD nano-aggregates are promising, as the particles exhibit improvements in aerosolization properties. PVA displayed potential in its unique particle morphology, which may have benefits in the re-dispersibility of the nano-aggregates in aqueous media. With the advantages of SFD and nanoparticulate technology, further tests can be carried out to optimize the aerosolization efficiency and re-dispersibility of the nano-aggregates for effective pulmonary drug delivery.
author2 Kunn Hadinoto Ong
author_facet Kunn Hadinoto Ong
Ng, Mabel Li Ling.
format Final Year Project
author Ng, Mabel Li Ling.
author_sort Ng, Mabel Li Ling.
title Pharmaceutical powder production by spray-freeze-drying technique : design and optimization of experimental parameters.
title_short Pharmaceutical powder production by spray-freeze-drying technique : design and optimization of experimental parameters.
title_full Pharmaceutical powder production by spray-freeze-drying technique : design and optimization of experimental parameters.
title_fullStr Pharmaceutical powder production by spray-freeze-drying technique : design and optimization of experimental parameters.
title_full_unstemmed Pharmaceutical powder production by spray-freeze-drying technique : design and optimization of experimental parameters.
title_sort pharmaceutical powder production by spray-freeze-drying technique : design and optimization of experimental parameters.
publishDate 2010
url http://hdl.handle.net/10356/40640
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