Isolation of tubulysins from myxobacteria.

• Main Author: Lee, Sean Mun Kit.
• Other Authors: Liu Chuan Fa
• Format: Final Year Project
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Bacteria
• Online Access: http://hdl.handle.net/10356/41829
• Institution: Nanyang Technological University

Myxobacteria are prokaryotes found commonly in soil that produces fruiting bodies and a diverse array of secondary metabolites. Tubulysins are highly potent anticancer compounds that are produced by most myxobacteria. Tubulysins disrupt microtubule networks of cancer cells leading to their inability...