Characterization of a novel P53 target gene, Heme Oxygenase (decycling) 1 (HMOX1)

• Main Author: Nam, Shin Yuen
• Other Authors: Koh Cheng Gee
• Format: Theses and Dissertations
• Language: English
• Published: 2010
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/42360
• Institution: Nanyang Technological University

The p53 tumour suppressor protein plays a pivotal role in coordinating the cellular response to a range of environmental and intracellular stresses. Multiple stress signals that activate p53 include hypoxia, telomere erosion, oncogenes and DNA damage, which is the best studied of them all. Activated p53 translocates into the nucleus and acts as a transcription factor to regulate its target genes, resulting in the anti-proliferative affects of p53 like cell cycle arrest, apoptosis, and DNA repair. The functions of p53 are regulated by several mechanisms including post-translation modifications, protein-protein interaction, etc.