Development of topoisomerase I inhibitors on the basis of structural variation of oligonucleotides.

Human topoisomerase I is essential for virtually every cellular DNA growth processes and has been regarded as a prime target for anticancer drugs due to its critical role in releasing the topological stress of DNA for replication and transcription. It was discovered in the past years that besides su...

Full description

Saved in:
Bibliographic Details
Main Author: Quek, Ngee Mien.
Other Authors: School of Physical and Mathematical Sciences
Format: Theses and Dissertations
Language:English
Published: 2011
Subjects:
Online Access:http://hdl.handle.net/10356/42860
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English