Development of topoisomerase I inhibitors on the basis of structural variation of oligonucleotides.

• Main Author: Quek, Ngee Mien.
• Other Authors: School of Physical and Mathematical Sciences
• Format: Theses and Dissertations
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Chemistry::Biochemistry
• Online Access: http://hdl.handle.net/10356/42860
• Institution: Nanyang Technological University

Human topoisomerase I is essential for virtually every cellular DNA growth processes and has been regarded as a prime target for anticancer drugs due to its critical role in releasing the topological stress of DNA for replication and transcription. It was discovered in the past years that besides su...