Part I Indium-mediated THP ring formation and transformation of halo group into hydroxyl group Part II Palladium-catalyzed direct arylation of cyclic enamides with arylmetallic reagents
This thesis comprises of two main parts:indium-mediated THP ring formation and functional group transformation, and palladium-catalyzed direct arylation of cyclic enamides with organometallic reagents via C-H functionalization.The thesis includes 5 Chapters. The Chapter 1 is about a one-pot total sy...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2011
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| Online Access: | https://hdl.handle.net/10356/43519 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | This thesis comprises of two main parts:indium-mediated THP ring formation and functional group transformation, and palladium-catalyzed direct arylation of cyclic enamides with organometallic reagents via C-H functionalization.The thesis includes 5 Chapters. The Chapter 1 is about a one-pot total synthesis of THP-ring natural products. In Chapter 2, the aerobic aqueous transformation of halo group into hydroxyl group via tin-free radical method was presented. In Chapter 3, synthesis of 4,4-dihalotetrahydropyrans via Prins cyclization has been developed. In Chapter 4, Pd(II)-catalyzed direct arylation of cyclic enamides was shown.In chapter 5, the copper-free, palladium-catalyzed Sonogashira cross-coupling reaction was reported. |
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