Part I Indium-mediated THP ring formation and transformation of halo group into hydroxyl group Part II Palladium-catalyzed direct arylation of cyclic enamides with arylmetallic reagents

• Main Author: Zhou, Hai
• Other Authors: Loh Teck Peng
• Format: Theses and Dissertations
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis
• Online Access: https://hdl.handle.net/10356/43519
• Institution: Nanyang Technological University

This thesis comprises of two main parts:indium-mediated THP ring formation and functional group transformation, and palladium-catalyzed direct arylation of cyclic enamides with organometallic reagents via C-H functionalization.The thesis includes 5 Chapters. The Chapter 1 is about a one-pot total synthesis of THP-ring natural products. In Chapter 2, the aerobic aqueous transformation of halo group into hydroxyl group via tin-free radical method was presented. In Chapter 3, synthesis of 4,4-dihalotetrahydropyrans via Prins cyclization has been developed. In Chapter 4, Pd(II)-catalyzed direct arylation of cyclic enamides was shown.In chapter 5, the copper-free, palladium-catalyzed Sonogashira cross-coupling reaction was reported.