Expression and purification of the herpes viral metallo-protein R2 for structural studies.

• Main Author: Lu, Si Yan.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Virology
• Online Access: http://hdl.handle.net/10356/45134
• Institution: Nanyang Technological University

Ribonucleotide reductase is the only enzyme that is involved in de novo synthesis of DNA. Herpes Virus Ribonucleotide reductase consists of two subunits R1 and R2, The activation of this enzyme is controlled by the binding of the allosteric sites on R1 and the radical generation in R2. C...