Determination of encephalomyocarditis viral diabetogenicity by a putative binding site of the viral capsid protein

• Main Authors: Notkins, Abner L., Yoon, Ho Sup, Jun, Hee-Sook, Kang, Yup, Kim, Ki Hwan, Yoon, Ji-Won
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Virology
• Online Access: https://hdl.handle.net/10356/94163; http://hdl.handle.net/10220/7489
• Institution: Nanyang Technological University

The molecular mechanism by which some, but not all, variants of encephalomyocarditis (EMC) virus selectively infect pancreatic beta-cells in mice and induce IDDM has been an enigma for more than a decade. We report here that the binding site of the EMC viral capsid protein VP1 determines viral diabe...