Coated magnetic carrier particles for targeted drug delivery
Magnetic drug targeting, using coated magnetic carrier particles (MCP), is an efficient method to localize drugs at the tumor site. In magnetically targeted drug delivery, MCP loaded with anti-cancer drugs are injected into the patient and an external magnetic field is used to concentrate MCP at the...
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| Format: | Theses and Dissertations |
| Language: | English |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/45161 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Magnetic drug targeting, using coated magnetic carrier particles (MCP), is an efficient method to localize drugs at the tumor site. In magnetically targeted drug delivery, MCP loaded with anti-cancer drugs are injected into the patient and an external magnetic field is used to concentrate MCP at the tumor site. Advantages include reduction in the drug
dose and minimization of systemic side effects. The objective of this work is the
synthesis, characterization and property evaluation of coated MCP, and experimental and
modelling studies of the efficacy with which such particles can be captured by an external
magnetic field.
Gold coated iron (Fe@Au) and polyvinylalcohol coated iron oxide (PVA-IO)
nanoparticles were synthesized and characterized by XRD, TEM, DLS, TGA, XPS, FTIR
and VSM techniques. |
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