Coated magnetic carrier particles for targeted drug delivery

• Main Author: Sibnath Kayal
• Other Authors: Raju Vijayaraghavan Ramanujan
• Format: Theses and Dissertations
• Language: English
• Published: 2011
• Subjects: DRNTU::Engineering::Materials::Biomaterials
• Online Access: https://hdl.handle.net/10356/45161
• Institution: Nanyang Technological University

Magnetic drug targeting, using coated magnetic carrier particles (MCP), is an efficient method to localize drugs at the tumor site. In magnetically targeted drug delivery, MCP loaded with anti-cancer drugs are injected into the patient and an external magnetic field is used to concentrate MCP at the tumor site. Advantages include reduction in the drug dose and minimization of systemic side effects. The objective of this work is the synthesis, characterization and property evaluation of coated MCP, and experimental and modelling studies of the efficacy with which such particles can be captured by an external magnetic field. Gold coated iron (Fe@Au) and polyvinylalcohol coated iron oxide (PVA-IO) nanoparticles were synthesized and characterized by XRD, TEM, DLS, TGA, XPS, FTIR and VSM techniques.