Nanoparticle-mediated photodynamic therapy (PDT) for enhanced anti-tumor effect
Photodynamic therapy (PDT) is a medical treatment that utilizes light and photosensitizers to treat a variety of diseases. However, due to tumor drug resistance, cancer cells utilize multiple mechanisms to prevent the accumulation of anti-cancer drugs at their intracellular site of action....
Saved in:
Main Author: | |
---|---|
Other Authors: | |
Format: | Final Year Project |
Language: | English |
Published: |
2011
|
Subjects: | |
Online Access: | http://hdl.handle.net/10356/45284 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
Summary: | Photodynamic therapy (PDT) is a medical treatment that utilizes light and
photosensitizers to treat a variety of diseases. However, due to tumor drug resistance,
cancer cells utilize multiple mechanisms to prevent the accumulation of anti-cancer drugs
at their intracellular site of action. In this project, Fe3O4@SiO2@SiO2 nanorattles
combined with photodynamic therapy (PDT) using methylene blue (MB) was designed to
investigate its anti-cancer efficiency in vitro. Positively charged MB was loaded onto
negatively charged Fe3O4@SiO2@SiO2 nanorattles through electrostatic interactions, and
the results showed that the MB-loaded Fe3O4@SiO2@SiO2 nanorattles exhibited greater
phototoxicity than free MB due to the increased cell uptake of anti-cancer drug delivery
vehicles. Moreover, for controlled release investigation, the release profile indicated that
the interaction between MB and Fe3O4@SiO2@SiO2 nanorattles was weakened in acidic
environments. Based on these findings, it is proposed that PDT mediated by
Fe3O4@SiO2@SiO2 nanorattles has potential for enhanced anti-tumor effect. |
---|