Characterization of the estrogenic activity of a synthetic adrenal steroid 17-α ethinyl androstenediol and its potential use in hormone replacement therapy.

This study demonstrates the estrogenic activity of 17-alpha ethinyl androstenediol (AED) in ER positive breast cancer cells MCF 7, T47D and CRL 1500 cells. Our findings suggest that AED binds to ER as AED significantly stimulated growth of ER positive breast cancer cells and induced the expression o...

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Bibliographic Details
Main Author: Tan, Vanessa Yuzhen.
Other Authors: Vaninirappuputhenpurayil Gopalan Reju
Format: Theses and Dissertations
Language:English
Published: 2011
Subjects:
Online Access:http://hdl.handle.net/10356/45321
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Institution: Nanyang Technological University
Language: English