Characterization of the estrogenic activity of a synthetic adrenal steroid 17-α ethinyl androstenediol and its potential use in hormone replacement therapy.

• Main Author: Tan, Vanessa Yuzhen.
• Other Authors: Vaninirappuputhenpurayil Gopalan Reju
• Format: Theses and Dissertations
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Human anatomy and physiology::Endocrinology
• Online Access: http://hdl.handle.net/10356/45321
• Institution: Nanyang Technological University

This study demonstrates the estrogenic activity of 17-alpha ethinyl androstenediol (AED) in ER positive breast cancer cells MCF 7, T47D and CRL 1500 cells. Our findings suggest that AED binds to ER as AED significantly stimulated growth of ER positive breast cancer cells and induced the expression o...