Elucidating the role of prolidase in impairment of insulin signaling via abnormalities in integrinβ1 signaling pathway.

• المؤلف الرئيسي: Ng, Genevieve Gek Fong.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: Final Year Project
• اللغة: English
• منشور في: 2011
• الموضوعات: DRNTU::Science::Biological sciences::Biochemistry; DRNTU::Science::Biological sciences::Human anatomy and physiology::Endocrinology
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/46187
• المؤسسة: Nanyang Technological University

In this research project, novel gene PEPD encoding for prolidase enzyme was found to be linked to Type 2 Diabetes Mellitus. We investigated the 1) differences in PEPD mRNA and protein expression in insulin-sensitive versus insulin-resistant muscle samples; and if 2) associated prolidase, in...