Elucidating the role of prolidase in impairment of insulin signaling via abnormalities in integrinβ1 signaling pathway.

• 主要作者: Ng, Genevieve Gek Fong.
• 其他作者: School of Biological Sciences
• 格式: Final Year Project
• 語言: English
• 出版: 2011
• 主題: DRNTU::Science::Biological sciences::Biochemistry; DRNTU::Science::Biological sciences::Human anatomy and physiology::Endocrinology
• 在線閱讀: http://hdl.handle.net/10356/46187

In this research project, novel gene PEPD encoding for prolidase enzyme was found to be linked to Type 2 Diabetes Mellitus. We investigated the 1) differences in PEPD mRNA and protein expression in insulin-sensitive versus insulin-resistant muscle samples; and if 2) associated prolidase, in...