Elucidating the role of prolidase in impairment of insulin signaling via abnormalities in integrinβ1 signaling pathway.

• Main Author: Ng, Genevieve Gek Fong.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Biochemistry; DRNTU::Science::Biological sciences::Human anatomy and physiology::Endocrinology
• Online Access: http://hdl.handle.net/10356/46187
• Institution: Nanyang Technological University

In this research project, novel gene PEPD encoding for prolidase enzyme was found to be linked to Type 2 Diabetes Mellitus. We investigated the 1) differences in PEPD mRNA and protein expression in insulin-sensitive versus insulin-resistant muscle samples; and if 2) associated prolidase, in...