Rac inactivation decreases cell adhesion strength in chronic myeloid leukaemia

• Main Author: Yang, Joan Xiaohui
• Other Authors: Liao Kin
• Format: Final Year Project
• Language: English
• Published: 2011
• Subjects: DRNTU::Science::Biological sciences::Cytology
• Online Access: http://hdl.handle.net/10356/45681
• Institution: Nanyang Technological University

Chronic myeloid leukemia is a hematological malignancy characterized by the reciprocal translocation between chromosomes 9 and 22, resulting in the expression of the constitutively active tyrosine kinase BCR-ABL. The treatment of chronic myeloid leukemia by the tyrosine kinase inhibitior, imatinib,...