Biosynthetic mechanism of antitumor enediyne natural products.

17 p.

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Bibliographic Details
Main Author:	Liang, Zhao-Xun.
Other Authors:	School of Biological Sciences
Format:	Research Report
Published:	2011
Subjects:	DRNTU::Science::Biological sciences::Biochemistry
Online Access:	http://hdl.handle.net/10356/46700
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Institution:	Nanyang Technological University

id	sg-ntu-dr.10356-46700
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spelling	sg-ntu-dr.10356-467002023-02-28T17:58:25Z Biosynthetic mechanism of antitumor enediyne natural products. Liang, Zhao-Xun. School of Biological Sciences DRNTU::Science::Biological sciences::Biochemistry 17 p. In the past three years, we have characterized two linear carbonyl-conjugated polyenes generated by the iterative polyketide synthase (PKS) involved in the biosynthesis of the 10- membered enediyne core of calicheamicin. The results provide insight into the mysterious biosynthetic mechanism of the unique enediyne. The carbonyl-conjugated polyene differs from the precursor for 9-membered enediyne, suggesting that the divergence of the 9- and 10- membered enediyne biosynthetic pathways starts at the PKS stage. ARC 7/07 2011-12-21T05:14:31Z 2011-12-21T05:14:31Z 2010 2010 Research Report http://hdl.handle.net/10356/46700 Nanyang Technological University application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
topic	DRNTU::Science::Biological sciences::Biochemistry
spellingShingle	DRNTU::Science::Biological sciences::Biochemistry Liang, Zhao-Xun. Biosynthetic mechanism of antitumor enediyne natural products.
description	17 p.
author2	School of Biological Sciences
author_facet	School of Biological Sciences Liang, Zhao-Xun.
format	Research Report
author	Liang, Zhao-Xun.
author_sort	Liang, Zhao-Xun.
title	Biosynthetic mechanism of antitumor enediyne natural products.
title_short	Biosynthetic mechanism of antitumor enediyne natural products.
title_full	Biosynthetic mechanism of antitumor enediyne natural products.
title_fullStr	Biosynthetic mechanism of antitumor enediyne natural products.
title_full_unstemmed	Biosynthetic mechanism of antitumor enediyne natural products.
title_sort	biosynthetic mechanism of antitumor enediyne natural products.
publishDate	2011
url	http://hdl.handle.net/10356/46700
_version_	1759856069669027840

Biosynthetic mechanism of antitumor enediyne natural products.

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