Modelling of zebrafish chorion mechanical property characterisation using an automatic microrobotic force sensing system

59 p.

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Bibliographic Details
Main Author:	Vidyalakshmi Janardhanan
Other Authors:	Ang Wei Tech
Format:	Theses and Dissertations
Published:	2011
Subjects:	DRNTU::Engineering::Mechanical engineering::Mechatronics
Online Access:	http://hdl.handle.net/10356/47154
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Institution:	Nanyang Technological University

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spelling	sg-ntu-dr.10356-471542023-03-11T17:03:40Z Modelling of zebrafish chorion mechanical property characterisation using an automatic microrobotic force sensing system Vidyalakshmi Janardhanan Ang Wei Tech School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering::Mechatronics 59 p. Micromanipulation techniques have come into the foray of science and engineering recently and have found varied applications ranging from microinjection, microforce sensing, mechanobiology and other precision engineering tasks. Intra-Cellular Sperm Injection (ICSI) techniques are prevalent in the medical field and involve the manipulation of cells at a micro or nano-level to facilitate desired results of fertilisation or Somatic Cell Nuclear Transfer (SCNT). Promising results have been generated over the past years with several accounts of successful fertilisation, however it is noticed that these tasks require a high degree of precision and accurate manoeuvrability. In addition, minimizing of biological contamination and high throughout operation has become the need of the hour. Robotic Microsurgery and Microrobotic manipulation have established a more precise carrying out such tasks. The feasibility and the repeatability of such an Automatic Microrobotic System are illustrated here. The system is extensively deployed for the characterisation of the mechanical properties of a biomembrane, thus numerically quantifying the biological "softening" properties of membrane. The force profiles are modelled into a polynomial expression and reverse-engineered to achieve force control at a microlevel. This force control is the characteristic feature of this system. The biological perspective is investigated by applying controlled indentations to the fertilised embryo and analysing the proteomics. It is also believed to be of varied application in the field of mechanobiology, where force control is of paramount significance to investigate and bring about a desired stress-induced biological changes or control of the same. The system also foresees various related applications in the field of developmental biology, proteomics assessments, Molecular and cell biology etc. Master of Science (Biomedical Engineering) 2011-12-27T06:29:52Z 2011-12-27T06:29:52Z 2009 2009 Thesis http://hdl.handle.net/10356/47154 Nanyang Technological University application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
topic	DRNTU::Engineering::Mechanical engineering::Mechatronics
spellingShingle	DRNTU::Engineering::Mechanical engineering::Mechatronics Vidyalakshmi Janardhanan Modelling of zebrafish chorion mechanical property characterisation using an automatic microrobotic force sensing system
description	59 p.
author2	Ang Wei Tech
author_facet	Ang Wei Tech Vidyalakshmi Janardhanan
format	Theses and Dissertations
author	Vidyalakshmi Janardhanan
author_sort	Vidyalakshmi Janardhanan
title	Modelling of zebrafish chorion mechanical property characterisation using an automatic microrobotic force sensing system
title_short	Modelling of zebrafish chorion mechanical property characterisation using an automatic microrobotic force sensing system
title_full	Modelling of zebrafish chorion mechanical property characterisation using an automatic microrobotic force sensing system
title_fullStr	Modelling of zebrafish chorion mechanical property characterisation using an automatic microrobotic force sensing system
title_full_unstemmed	Modelling of zebrafish chorion mechanical property characterisation using an automatic microrobotic force sensing system
title_sort	modelling of zebrafish chorion mechanical property characterisation using an automatic microrobotic force sensing system
publishDate	2011
url	http://hdl.handle.net/10356/47154
_version_	1761781757964713984

Modelling of zebrafish chorion mechanical property characterisation using an automatic microrobotic force sensing system

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