X-ray crystallographic characterization of heavy metal-nucleosome association and nucleosome core particle composed of novel DNA sequences
148 p.
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2011
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sg-ntu-dr.10356-474412023-02-28T18:32:37Z X-ray crystallographic characterization of heavy metal-nucleosome association and nucleosome core particle composed of novel DNA sequences Mohideen Abdul Kareem Curtis Alexander Davey School of Biological Sciences DRNTU::Science::Biological sciences::Genetics 148 p. Metal ions with strong carcinogenic potential, including Cd2+, Ni2+, Co2+ and Cr6+, are known to play a significant role in disrupting a broad range of cellular processes. However, the precise mechanisms by which heavy metals exert their carcinogenic effects are not clear and require further studies. Recent developments suggest that epigenetic mechanisms may play an important role in activating or silencing the expression of genes, which are critical for driving the metal-induced pathogenesis. In our study, using X-ray crystallography, we characterized the binding of Ni2+ and Co2+ to the nucleosome core particle (NCP) - the fundamental entity of chromatin - in order to comprehend their site-selectivity and influence on the structure of nucleosomal DNA. DOCTOR OF PHILOSOPHY (SBS) 2011-12-27T08:17:32Z 2011-12-27T08:17:32Z 2010 2010 Thesis Mohideen, A. K. (2010). X-ray crystallographic characterization of heavy metal-nucleosome association and nucleosome core particle composed of novel DNA sequences. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/47441 10.32657/10356/47441 Nanyang Technological University application/pdf |
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DRNTU::Science::Biological sciences::Genetics Mohideen Abdul Kareem X-ray crystallographic characterization of heavy metal-nucleosome association and nucleosome core particle composed of novel DNA sequences |
| description |
148 p. |
| author2 |
Curtis Alexander Davey |
| author_facet |
Curtis Alexander Davey Mohideen Abdul Kareem |
| format |
Theses and Dissertations |
| author |
Mohideen Abdul Kareem |
| author_sort |
Mohideen Abdul Kareem |
| title |
X-ray crystallographic characterization of heavy metal-nucleosome association and nucleosome core particle composed of novel DNA sequences |
| title_short |
X-ray crystallographic characterization of heavy metal-nucleosome association and nucleosome core particle composed of novel DNA sequences |
| title_full |
X-ray crystallographic characterization of heavy metal-nucleosome association and nucleosome core particle composed of novel DNA sequences |
| title_fullStr |
X-ray crystallographic characterization of heavy metal-nucleosome association and nucleosome core particle composed of novel DNA sequences |
| title_full_unstemmed |
X-ray crystallographic characterization of heavy metal-nucleosome association and nucleosome core particle composed of novel DNA sequences |
| title_sort |
x-ray crystallographic characterization of heavy metal-nucleosome association and nucleosome core particle composed of novel dna sequences |
| publishDate |
2011 |
| url |
https://hdl.handle.net/10356/47441 |
| _version_ |
1759853439213371392 |