Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction

149 p.

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Bibliographic Details
Main Author:	Wu, Bin
Other Authors:	Curtis Alexander Davey
Format:	Theses and Dissertations
Published:	2011
Subjects:	RNTU::Science::Biological sciences
Online Access:	https://hdl.handle.net/10356/47445
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Institution:	Nanyang Technological University

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spelling	sg-ntu-dr.10356-474452023-02-28T18:35:15Z Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction Wu, Bin Curtis Alexander Davey School of Biological Sciences RNTU::Science::Biological sciences 149 p. The nucleosome is an essential structural and functional feature of eukaryotic chromatin, which allows for hierarchical genomic regulation. Not only are histones heavily involved in genomic events, nucleosomal DNA is found to possess structural characteristics important for genomic function as well. The discovery of chromatin site-selective compounds could allow targeting of specific genes, which coincide with weak points of cancer cells. DOCTOR OF PHILOSOPHY (SBS) 2011-12-27T08:17:56Z 2011-12-27T08:17:56Z 2009 2009 Thesis Wu, B. (2009). Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/47445 10.32657/10356/47445 Nanyang Technological University application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
topic	RNTU::Science::Biological sciences
spellingShingle	RNTU::Science::Biological sciences Wu, Bin Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction
description	149 p.
author2	Curtis Alexander Davey
author_facet	Curtis Alexander Davey Wu, Bin
format	Theses and Dissertations
author	Wu, Bin
author_sort	Wu, Bin
title	Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction
title_short	Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction
title_full	Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction
title_fullStr	Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction
title_full_unstemmed	Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction
title_sort	structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction
publishDate	2011
url	https://hdl.handle.net/10356/47445
_version_	1759854119224344576

Structural, dynamics and site selectivity investigations of platinum anticancer drug-nucleosome interaction

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