Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents

Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents

Platinum-based anticancer drugs act therapeutically by forming DNA adducts, but suffer from severe toxicity and resistance problems, which have not been overcome in spite of decades of research. And yet defined chromatin targets have generally not been considered in the drug development process. Her...

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Bibliographic Details
Main Authors: Chin, Chee Fei, Dröge, Peter, Ang, Wee Han, Chua, Eugene Yue Dao, Davey, Gabriela Elzbieta, Davey, Curtis Alexander
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2015
Subjects:
Biological Sciences
Online Access:https://hdl.handle.net/10356/81033
http://hdl.handle.net/10220/39105
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/81033
http://hdl.handle.net/10220/39105

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