Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents

• Main Authors: Chin, Chee Fei, Dröge, Peter, Ang, Wee Han, Chua, Eugene Yue Dao, Davey, Gabriela Elzbieta, Davey, Curtis Alexander
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: Biological Sciences
• Online Access: https://hdl.handle.net/10356/81033; http://hdl.handle.net/10220/39105
• Institution: Nanyang Technological University

Platinum-based anticancer drugs act therapeutically by forming DNA adducts, but suffer from severe toxicity and resistance problems, which have not been overcome in spite of decades of research. And yet defined chromatin targets have generally not been considered in the drug development process. Her...