Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents

• المؤلفون الرئيسيون: Chin, Chee Fei, Dröge, Peter, Ang, Wee Han, Chua, Eugene Yue Dao, Davey, Gabriela Elzbieta, Davey, Curtis Alexander
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: Biological Sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/81033; http://hdl.handle.net/10220/39105
• المؤسسة: Nanyang Technological University

Platinum-based anticancer drugs act therapeutically by forming DNA adducts, but suffer from severe toxicity and resistance problems, which have not been overcome in spite of decades of research. And yet defined chromatin targets have generally not been considered in the drug development process. Her...