Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum

199 p.

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Bibliographic Details
Main Author:	Hu, Guang An
Other Authors:	Zbynek Bozdech
Format:	Theses and Dissertations
Published:	2011
Subjects:	DRNTU::Science::Biological sciences::Microbiology::Virology
Online Access:	https://hdl.handle.net/10356/47451
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Institution:	Nanyang Technological University

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spelling	sg-ntu-dr.10356-474512023-02-28T18:49:43Z Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum Hu, Guang An Zbynek Bozdech School of Biological Sciences DRNTU::Science::Biological sciences::Microbiology::Virology 199 p. Plasmodium falciparum is the most causative agent of the deadliest form of human malaria responsible for around 2 million deaths in the world. Even 6 years after the genome sequencing, more than 50 per cent genes of P. falciparum remain functionally uncharacterized. In this work we generated large functional datasets and systematically analyze these data combining other public functional datasets to characterize gene function, cellular process and gene regulation in P. falciparum. We developed the program OligoRankPick which uses a weighted rank-based strategy for the design of long oligonucleotide DNA microarrays. OligoRankPick does not rely on direct oligonucleotide exclusion by parameter cutoffs but instead optimizes all parameters in context of each other. Using this program we have designed several long oligonucleotide DNA microarrays for the parasitic species including P. falciparum, P. vivax and pan-rodent malaria. Based on the designed DNA microarray, we report on extensive transcriptional profiling of P. falciparum parasites using 20 small molecular compounds including several common antimalarial drugs. Diverse gene responses were observed in different drug or compound treatments and this perturbation data has a high predictive accuracy of functionally related genes based on their transcriptional regulation. DOCTOR OF PHILOSOPHY (SBS) 2011-12-27T08:18:31Z 2011-12-27T08:18:31Z 2009 2009 Thesis Hu, G. A. (2009). Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/47451 10.32657/10356/47451 Nanyang Technological University application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
topic	DRNTU::Science::Biological sciences::Microbiology::Virology
spellingShingle	DRNTU::Science::Biological sciences::Microbiology::Virology Hu, Guang An Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum
description	199 p.
author2	Zbynek Bozdech
author_facet	Zbynek Bozdech Hu, Guang An
format	Theses and Dissertations
author	Hu, Guang An
author_sort	Hu, Guang An
title	Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum
title_short	Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum
title_full	Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum
title_fullStr	Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum
title_full_unstemmed	Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum
title_sort	transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum
publishDate	2011
url	https://hdl.handle.net/10356/47451
_version_	1759857951007309824

Transcriptional profiling and network-based gene annotations of human malaria parasite plasmodium falciparum

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