Surface modification to improve blood compatibility
Heparin is one of the most intensively studied anticoagulants. This paper demonstrates various approaches to immobilize heparin on bio-substrate, i.e. chitosan films and PCL films. End-point bonded heparin surface is believed to have superior anticoagulation property. Therefore, Schiff base reaction...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/48441 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Heparin is one of the most intensively studied anticoagulants. This paper demonstrates various approaches to immobilize heparin on bio-substrate, i.e. chitosan films and PCL films. End-point bonded heparin surface is believed to have superior anticoagulation property. Therefore, Schiff base reaction was employed to obtain end-point attached heparin on chitosan films. Moreover, the O2 plasma treatment was used to achieve the immobilization of chitosan-heparin conjugation onto PCL surface. Water contact angle and Fourier transformed infrared spectroscopy was to characterize the modified surface properties. The surface composition has changed and resulted into a more hydrophilic surface. In vitro experiments were conducted to examine the surface anticoagulation property accordingly. As a result, the heparinized surface prevented the thrombosis formation better than other. |
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