Surface modification to improve blood compatibility

• Main Author: Xiao, Hongling
• Other Authors: Subramanian Venkatraman
• Format: Final Year Project
• Language: English
• Published: 2012
• Subjects: DRNTU::Engineering::Materials::Biomaterials
• Online Access: http://hdl.handle.net/10356/48441
• Institution: Nanyang Technological University

Heparin is one of the most intensively studied anticoagulants. This paper demonstrates various approaches to immobilize heparin on bio-substrate, i.e. chitosan films and PCL films. End-point bonded heparin surface is believed to have superior anticoagulation property. Therefore, Schiff base reaction was employed to obtain end-point attached heparin on chitosan films. Moreover, the O2 plasma treatment was used to achieve the immobilization of chitosan-heparin conjugation onto PCL surface. Water contact angle and Fourier transformed infrared spectroscopy was to characterize the modified surface properties. The surface composition has changed and resulted into a more hydrophilic surface. In vitro experiments were conducted to examine the surface anticoagulation property accordingly. As a result, the heparinized surface prevented the thrombosis formation better than other.