The market potential of next generation drug hepatotoxicity screening platforms.

Drug development is costly and expensive. Despite increased investments in the pharmaceutical industry, there remains a concomitant productivity gap due to high drug attrition rate during late clinical trials. With unforeseen human hepatotoxicity a key factor contributing to the high drug attrition...

Full description

Saved in:
Bibliographic Details
Main Author: Chin, Pei Hui.
Other Authors: School of Biological Sciences
Format: Final Year Project
Language:English
Published: 2012
Subjects:
Online Access:http://hdl.handle.net/10356/48794
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-48794
record_format dspace
spelling sg-ntu-dr.10356-487942023-02-28T18:00:28Z The market potential of next generation drug hepatotoxicity screening platforms. Chin, Pei Hui. School of Biological Sciences Cho Nam-Joon DRNTU::Science Drug development is costly and expensive. Despite increased investments in the pharmaceutical industry, there remains a concomitant productivity gap due to high drug attrition rate during late clinical trials. With unforeseen human hepatotoxicity a key factor contributing to the high drug attrition rate, there is a pressing need to improve on traditional pre-clinical in-vitro drug hepatotoxicity screening platforms (IVHSPs) to prevent further wastage of limited resources, which is done by emerging technologies such as tissue engineering. This paper aims to investigate the market potential of these improved next-generation IVHSPs by surveying the in-vitro ADME/Tox market and the CROs market and identify current trends, challenges and opportunities within these markets. Despite difficult challenges within both markets, the long-term need to increase the number of drugs within the drug development pipeline, together with the structural shift of drug discovery outsourcing will drive long-term growth of both markets, increasing the market potential of these new generation IVHSPs. In addition, this paper also investigated the marketability of locally invented IVHSPs by investigating the strengths, weaknesses, opportunities and threats within Singapore’s biomedical sector. With strong local research infrastructure and trade-oriented economy, locally invented IVHSPs can be pushed into emerging markets within the region, increasing marketability. Bachelor of Science in Biological Sciences 2012-05-09T06:50:47Z 2012-05-09T06:50:47Z 2012 2012 Final Year Project (FYP) http://hdl.handle.net/10356/48794 en Nanyang Technological University 29 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science
spellingShingle DRNTU::Science
Chin, Pei Hui.
The market potential of next generation drug hepatotoxicity screening platforms.
description Drug development is costly and expensive. Despite increased investments in the pharmaceutical industry, there remains a concomitant productivity gap due to high drug attrition rate during late clinical trials. With unforeseen human hepatotoxicity a key factor contributing to the high drug attrition rate, there is a pressing need to improve on traditional pre-clinical in-vitro drug hepatotoxicity screening platforms (IVHSPs) to prevent further wastage of limited resources, which is done by emerging technologies such as tissue engineering. This paper aims to investigate the market potential of these improved next-generation IVHSPs by surveying the in-vitro ADME/Tox market and the CROs market and identify current trends, challenges and opportunities within these markets. Despite difficult challenges within both markets, the long-term need to increase the number of drugs within the drug development pipeline, together with the structural shift of drug discovery outsourcing will drive long-term growth of both markets, increasing the market potential of these new generation IVHSPs. In addition, this paper also investigated the marketability of locally invented IVHSPs by investigating the strengths, weaknesses, opportunities and threats within Singapore’s biomedical sector. With strong local research infrastructure and trade-oriented economy, locally invented IVHSPs can be pushed into emerging markets within the region, increasing marketability.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Chin, Pei Hui.
format Final Year Project
author Chin, Pei Hui.
author_sort Chin, Pei Hui.
title The market potential of next generation drug hepatotoxicity screening platforms.
title_short The market potential of next generation drug hepatotoxicity screening platforms.
title_full The market potential of next generation drug hepatotoxicity screening platforms.
title_fullStr The market potential of next generation drug hepatotoxicity screening platforms.
title_full_unstemmed The market potential of next generation drug hepatotoxicity screening platforms.
title_sort market potential of next generation drug hepatotoxicity screening platforms.
publishDate 2012
url http://hdl.handle.net/10356/48794
_version_ 1759856938037805056