The market potential of next generation drug hepatotoxicity screening platforms.
Drug development is costly and expensive. Despite increased investments in the pharmaceutical industry, there remains a concomitant productivity gap due to high drug attrition rate during late clinical trials. With unforeseen human hepatotoxicity a key factor contributing to the high drug attrition...
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sg-ntu-dr.10356-487942023-02-28T18:00:28Z The market potential of next generation drug hepatotoxicity screening platforms. Chin, Pei Hui. School of Biological Sciences Cho Nam-Joon DRNTU::Science Drug development is costly and expensive. Despite increased investments in the pharmaceutical industry, there remains a concomitant productivity gap due to high drug attrition rate during late clinical trials. With unforeseen human hepatotoxicity a key factor contributing to the high drug attrition rate, there is a pressing need to improve on traditional pre-clinical in-vitro drug hepatotoxicity screening platforms (IVHSPs) to prevent further wastage of limited resources, which is done by emerging technologies such as tissue engineering. This paper aims to investigate the market potential of these improved next-generation IVHSPs by surveying the in-vitro ADME/Tox market and the CROs market and identify current trends, challenges and opportunities within these markets. Despite difficult challenges within both markets, the long-term need to increase the number of drugs within the drug development pipeline, together with the structural shift of drug discovery outsourcing will drive long-term growth of both markets, increasing the market potential of these new generation IVHSPs. In addition, this paper also investigated the marketability of locally invented IVHSPs by investigating the strengths, weaknesses, opportunities and threats within Singapore’s biomedical sector. With strong local research infrastructure and trade-oriented economy, locally invented IVHSPs can be pushed into emerging markets within the region, increasing marketability. Bachelor of Science in Biological Sciences 2012-05-09T06:50:47Z 2012-05-09T06:50:47Z 2012 2012 Final Year Project (FYP) http://hdl.handle.net/10356/48794 en Nanyang Technological University 29 p. application/pdf |
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DRNTU::Science Chin, Pei Hui. The market potential of next generation drug hepatotoxicity screening platforms. |
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Drug development is costly and expensive. Despite increased investments in the pharmaceutical industry, there remains a concomitant productivity gap due to high drug attrition rate during late clinical trials. With unforeseen human hepatotoxicity a key factor contributing to the high drug attrition rate, there is a pressing need to improve on traditional pre-clinical in-vitro drug hepatotoxicity screening platforms (IVHSPs) to prevent further wastage of limited resources, which is done by emerging technologies such as tissue engineering. This paper aims to investigate the market potential of these improved next-generation IVHSPs by surveying the in-vitro ADME/Tox market and the CROs market and identify current trends, challenges and opportunities within these markets. Despite difficult challenges within both markets, the long-term need to increase the number of drugs within the drug development pipeline, together with the structural shift of drug discovery outsourcing will drive long-term growth of both markets, increasing the market potential of these new generation IVHSPs. In addition, this paper also investigated the marketability of locally invented IVHSPs by investigating the strengths, weaknesses, opportunities and threats within Singapore’s biomedical sector. With strong local research infrastructure and trade-oriented economy, locally invented IVHSPs can be pushed into emerging markets within the region, increasing marketability. |
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School of Biological Sciences |
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School of Biological Sciences Chin, Pei Hui. |
format |
Final Year Project |
author |
Chin, Pei Hui. |
author_sort |
Chin, Pei Hui. |
title |
The market potential of next generation drug hepatotoxicity screening platforms. |
title_short |
The market potential of next generation drug hepatotoxicity screening platforms. |
title_full |
The market potential of next generation drug hepatotoxicity screening platforms. |
title_fullStr |
The market potential of next generation drug hepatotoxicity screening platforms. |
title_full_unstemmed |
The market potential of next generation drug hepatotoxicity screening platforms. |
title_sort |
market potential of next generation drug hepatotoxicity screening platforms. |
publishDate |
2012 |
url |
http://hdl.handle.net/10356/48794 |
_version_ |
1759856938037805056 |