Drug target discovery in human malaria; inhibition of histone deacetylases (HDAC) in Plasmodium falciparum.

• Main Author: Chua, Rui Jing.
• Other Authors: Zbynek Bozdech
• Format: Final Year Project
• Language: English
• Published: 2012
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/49389
• Institution: Nanyang Technological University

The emergence of drug-resistance Plasmodium falciparum to the current chemotherapies indicates an urgent need to discover new drug target for malarial control. The intricate transcriptome of the intraerythrocytic developmental cycle (IDC) of Plasmodium falciparum raises many questions about the mech...