Evaluation of a new type of rifamycin-bonded chiral stationary phase in high-performance liquid chromatography.
Rifamycin-capped (3-(C-methylcalix[4]resorcinarene)-2-hydroxypropoxy)-propylsilyl-appended silica particles (RMCR-HPS), a new type of substituted methylcalix[4]resorcinarene-bonded chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC), have been synthesized by the treatment...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2012
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| Online Access: | http://hdl.handle.net/10356/49426 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Rifamycin-capped (3-(C-methylcalix[4]resorcinarene)-2-hydroxypropoxy)-propylsilyl-appended silica particles (RMCR-HPS), a new type of substituted methylcalix[4]resorcinarene-bonded chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC), have been synthesized by the treatment of bromoacetate-substituted-(3-(C-methylcalix[4]resorcinarene)-2-hydroxypropoxy)-propylsilyl-appended silica particles (BAMCR-HPS) with rifamycin SB in anhydrous acetonitrile. The stationary phase is characterized by means of elemental analysis. This new CSP has a chiral selector consisting of two chiral recognition sites - rifamycin and methylcalix[4]resorcinarene.These two chiral recognition sites contain many different types of functional groups which provide various interactions with chiral compounds so as to enhance chiral recognition of the new CSP. |
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