Surface enhanced Raman-scattering protein sensor
Raman spectroscopy is used to study vibrational modes in molecules. Depending on the constituent atomic masses and the molecular-bond strengths, each molecule possesses a unique set of vibrational frequencies, which allows it to be identified even from a complex background consisting of different ot...
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sg-ntu-dr.10356-497892023-07-07T17:10:48Z Surface enhanced Raman-scattering protein sensor Loh, Wai Kit. Ng Beng Koon School of Electrical and Electronic Engineering A*STAR Data Storage Institute DRNTU::Engineering::Electrical and electronic engineering::Nanoelectronics Raman spectroscopy is used to study vibrational modes in molecules. Depending on the constituent atomic masses and the molecular-bond strengths, each molecule possesses a unique set of vibrational frequencies, which allows it to be identified even from a complex background consisting of different other molecular species. In Surface Enhanced Raman Spectroscopy (SERS), unique optical property of metallic (example like Gold (Au) or Silver (Ag)) nano-structures are utilized to generate strong light fields localized near nano-protrusions or nano-crevices on the surface. An analyte placed or absorbed within these “hot-spot” areas would experience a strong excitation, resulting in an amplification of the Raman emission. One can thus use SERS hot-spots as an ultrasensitive sensing element for detecting specific molecules in a complex mixture. The project will investigate the use of SERS for protein sensing in bio-fluids with our collaborators in the Singapore Bio-imaging Consortium. Bachelor of Engineering 2012-05-24T03:44:16Z 2012-05-24T03:44:16Z 2012 2012 Final Year Project (FYP) http://hdl.handle.net/10356/49789 en Nanyang Technological University 72 p. application/pdf |
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DRNTU::Engineering::Electrical and electronic engineering::Nanoelectronics Loh, Wai Kit. Surface enhanced Raman-scattering protein sensor |
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Raman spectroscopy is used to study vibrational modes in molecules. Depending on the constituent atomic masses and the molecular-bond strengths, each molecule possesses a unique set of vibrational frequencies, which allows it to be identified even from a complex background consisting of different other molecular species. In Surface Enhanced Raman Spectroscopy (SERS), unique optical property of metallic (example like Gold (Au) or Silver (Ag)) nano-structures are utilized to generate strong light fields localized near nano-protrusions or nano-crevices on the surface. An analyte placed or absorbed within these “hot-spot” areas would experience a strong excitation, resulting in an amplification of the Raman emission. One can thus use SERS hot-spots as an ultrasensitive sensing element for detecting specific molecules in a complex mixture. The project will investigate the use of SERS for protein sensing in bio-fluids with our collaborators in the Singapore Bio-imaging Consortium. |
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Ng Beng Koon |
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Ng Beng Koon Loh, Wai Kit. |
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Final Year Project |
author |
Loh, Wai Kit. |
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Loh, Wai Kit. |
title |
Surface enhanced Raman-scattering protein sensor |
title_short |
Surface enhanced Raman-scattering protein sensor |
title_full |
Surface enhanced Raman-scattering protein sensor |
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Surface enhanced Raman-scattering protein sensor |
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Surface enhanced Raman-scattering protein sensor |
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surface enhanced raman-scattering protein sensor |
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2012 |
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http://hdl.handle.net/10356/49789 |
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1772827197113892864 |