Chiral secondary amine catalyzed asymmetric cascade reactions
Enantioselective organocatalytic cascade reactions have attracted more and more attention during recent years. Chiral secondary amine catalyst played an important role in this kind of reaction. Hence three novel investigations of chiral secondary amine catalyzed asymmetric cascade reactions were dev...
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sg-ntu-dr.10356-506072023-02-28T23:57:23Z Chiral secondary amine catalyzed asymmetric cascade reactions Dai, Lu Loh Teck Peng Zhong Guofu School of Physical and Mathematical Sciences Park Cheol-Min DRNTU::Science::Chemistry Enantioselective organocatalytic cascade reactions have attracted more and more attention during recent years. Chiral secondary amine catalyst played an important role in this kind of reaction. Hence three novel investigations of chiral secondary amine catalyzed asymmetric cascade reactions were developed. L-proline and silyl prolinol ether were utilized in the projects, which efficiently catalyzed three different cascade processes: α-amination/condensation/nitrone [3+2] cycloaddition, aza-Michael-Michael-acetalization, and oxo-Michael-Michael-Michael-aldol reactions. All the reactions showed high to excellent diastereoselectivity and enantioselectivity in multi stereogenic centers and hence constructed complicated molecules. CHEMISTRY and BIOLOGICAL CHEMISTRY 2012-07-27T01:15:20Z 2012-07-27T01:15:20Z 2012 2012 Thesis Dai, L. (2012). Chiral secondary amine catalyzed asymmetric cascade reactions. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/50607 10.32657/10356/50607 en 129 p. application/pdf |
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DRNTU::Science::Chemistry Dai, Lu Chiral secondary amine catalyzed asymmetric cascade reactions |
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Enantioselective organocatalytic cascade reactions have attracted more and more attention during recent years. Chiral secondary amine catalyst played an important role in this kind of reaction. Hence three novel investigations of chiral secondary amine catalyzed asymmetric cascade reactions were developed.
L-proline and silyl prolinol ether were utilized in the projects, which efficiently catalyzed three different cascade processes: α-amination/condensation/nitrone [3+2] cycloaddition, aza-Michael-Michael-acetalization, and oxo-Michael-Michael-Michael-aldol reactions. All the reactions showed high to excellent diastereoselectivity and enantioselectivity in multi stereogenic centers and hence constructed complicated molecules. |
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Loh Teck Peng |
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Loh Teck Peng Dai, Lu |
format |
Theses and Dissertations |
author |
Dai, Lu |
author_sort |
Dai, Lu |
title |
Chiral secondary amine catalyzed asymmetric cascade reactions |
title_short |
Chiral secondary amine catalyzed asymmetric cascade reactions |
title_full |
Chiral secondary amine catalyzed asymmetric cascade reactions |
title_fullStr |
Chiral secondary amine catalyzed asymmetric cascade reactions |
title_full_unstemmed |
Chiral secondary amine catalyzed asymmetric cascade reactions |
title_sort |
chiral secondary amine catalyzed asymmetric cascade reactions |
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2012 |
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https://hdl.handle.net/10356/50607 |
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