[Withdrawn] Molecular mechanisms behind skeletal muscle wasting

• Main Author: Sudarsanareddy Lokireddy
• Other Authors: Ravi Kambadur
• Format: Theses and Dissertations
• Language: English
• Published: 2012
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/50710
• Institution: Nanyang Technological University

Myostatin, a member of TGF-β superfamily, is a potent negative regulator of skeletal muscle growth and development. Current literature demonstrates that elevated levels of circulatory Myostatin activates the ubiquitin-proteasome pathway, which leads to skeletal muscle wasting. However, the exact sig...