Translation termination mechanism studied by solution state NMR

• المؤلف الرئيسي: Li, Yan
• مؤلفون آخرون: Konstantin Pervushin
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2012
• الموضوعات: DRNTU::Science::Biological sciences::Biochemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/50711

Translation termination occurs when one of three stop-codons (UAA, UGA, or UAG) in mRNA reaches the ribosomal A site. In eukaryotes, class-I release factor (eRF1) directly recognizes all three stop-codons in the A site on the small ribosomal subunit and stimulates peptide release. N-domain of eRF1 p...