NMR approach to characterize Bcl-xl structure and interaction mechanism in membrane state

Bcl-2 family proteins play central roles in the apoptotic regulation at the mitochondrial membrane. Bcl-XL belongs to the anti-apoptotic subfamily of the Bcl-2 family. It interacts with pro-apoptotic subfamilies to inhibit them from forming pores on the mitochondrial membrane. Our current understand...

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Bibliographic Details
Main Author: Liu, Wei
Other Authors: Yoon Ho Sup
Format: Theses and Dissertations
Language:English
Published: 2014
Subjects:
Online Access:https://hdl.handle.net/10356/55292
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Institution: Nanyang Technological University
Language: English