Coating studies of intra-ocular lens with drug delivery
Current post-operative regime of cataract surgery involves a short course of antibiotic eye drops to prevent endophthalmitis. To replace current administration of eye drops, biodegradable attachment ring with drug eluting feature is fabricated using spray coater; with a customised mandrel to produce...
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| Format: | Final Year Project |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/52082 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Current post-operative regime of cataract surgery involves a short course of antibiotic eye drops to prevent endophthalmitis. To replace current administration of eye drops, biodegradable attachment ring with drug eluting feature is fabricated using spray coater; with a customised mandrel to produce even hooks that can be clipped onto the intraocular lens implant. In vitro drug release study has shown that ring with sandwich configuration is capable of a drug release of above 0.3% bioavailability of levofloxacin in eye drop for a period of more than 2 weeks. In vitro degradation has shown that the weight average molecular weight of PLC with 15% levofloxacin has similar degradation profile as PLC without levofloxacin. |
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