Coating studies of intra-ocular lens with drug delivery

• Main Author: Wu, Shiling.
• Other Authors: School of Materials Science and Engineering
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering
• Online Access: http://hdl.handle.net/10356/52082
• Institution: Nanyang Technological University

Current post-operative regime of cataract surgery involves a short course of antibiotic eye drops to prevent endophthalmitis. To replace current administration of eye drops, biodegradable attachment ring with drug eluting feature is fabricated using spray coater; with a customised mandrel to produce even hooks that can be clipped onto the intraocular lens implant. In vitro drug release study has shown that ring with sandwich configuration is capable of a drug release of above 0.3% bioavailability of levofloxacin in eye drop for a period of more than 2 weeks. In vitro degradation has shown that the weight average molecular weight of PLC with 15% levofloxacin has similar degradation profile as PLC without levofloxacin.