OncomiR-138 targets genes involved in senescence and its inhibition induces growth arrest of malignant gliomas.

• Main Author: Malini Rethnam.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/52897
• Institution: Nanyang Technological University

Glioblastoma Multiforme (GBM) is the most aggressive types of brain cancer with a median lifespan of 12 months. Recent studies have reported elevated expression of miR-138 in Glioma Stem cells (GSCs) and demonstrated that knocking miR-138 down prevented tumor progression, though the exact downstream...