Efforts towards the total synthesis of aspergillide a based on biomass.

• Main Author: Sun, Lin.
• Other Authors: Loh Teck Peng
• Format: Theses and Dissertations
• Language: English
• Published: 2013
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/52914
• Institution: Nanyang Technological University

Nowadays, the modern society is confronted with increasingly serious environmental and social problems caused by human excessive reliability on fossil fuels. These critical problems might be released with the help of biomass, which has the potential function to play as a renewable energy due to its abundant and cheap resources. The transformation of biomass into high value chemicals through some chemical, physical as well as biological methods, is prerequisite and indispensable for the realization of this potential. The emphasis of this thesis is focused on the chemical transformations of biomass into high value chemicals. In the first chapter, the composition, classification, resource and importance of biomass will be illustrated respectively. In the first part of chapter 1, a novel methodology of converting glucose from biomass into hydroxymethylfurfural (HMF), which is an important platform compound for numerous organic synthetic strategies, would be illustrated in detail as shown in the following scheme. In addition, the proposed mechanism for this chemical conversion would also be discussed in chapter 1. In the second chapter, a practicable approach will be elaborated in detail, which is focused on the chemical transformation of biomass into the natural product named aspergillide A, which features an unique molecular architecture and pharmaceutical activity.