Structural basis of interaction between proline-rich sequence of PNRC2 and EVH1 domain of hDcp1a and its implications in mRNA decapping

• 主要作者: Lai, Ethan Tingfeng
• 其他作者: Song Haiwei
• 格式: Theses and Dissertations
• 語言: English
• 出版: 2013
• 主題: DRNTU::Science::Biological sciences::Molecular biology
• 在線閱讀: https://hdl.handle.net/10356/53728
• 機構: Nanyang Technological University

Nonsense-mediated mRNA decay (NMD) is an important mRNA surveillance system that maintains the integrity of transcripts by removing aberrant mRNAs harbouring premature termination codons (PTCs). In the absence of NMD, truncated proteins with dominant negative or potentially deleterious gain of funct...