Structural basis of interaction between proline-rich sequence of PNRC2 and EVH1 domain of hDcp1a and its implications in mRNA decapping

• Main Author: Lai, Ethan Tingfeng
• Other Authors: Song Haiwei
• Format: Theses and Dissertations
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/53728
• Institution: Nanyang Technological University

Nonsense-mediated mRNA decay (NMD) is an important mRNA surveillance system that maintains the integrity of transcripts by removing aberrant mRNAs harbouring premature termination codons (PTCs). In the absence of NMD, truncated proteins with dominant negative or potentially deleterious gain of funct...