Development of a new strategy for inducible and reversible gene knockout.

• Main Author: Tan, Hanrong.
• Other Authors: Klaus Erik Karjalainen
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/53790
• Institution: Nanyang Technological University

The ability to inactivate gene function has contributed to functional genetics studies. Current techniques of gene knockout using Cre-loxP recombination and RNAi have achieved varying degrees of success despite certain limitations. To overcome these limitations, we initiated the development...