Molecular interactions between Parkin and FBXO7 and links with induced dopaminergic neuron degeneration in Parkinson's disease.

• Main Author: Tang, Alyssa Meiyan.
• Other Authors: School of Biological Sciences
• Format: Final Year Project
• Language: English
• Published: 2013
• Subjects: DRNTU::Science
• Online Access: http://hdl.handle.net/10356/53828
• Institution: Nanyang Technological University

Mitophagy has received much attention regarding the pathogenesis of PD. However, mitophagy studies have been encumbered by cell quantities, which will interfere with mitochondria readings. By double-staining cells with NAO and Hoechst after inducing mitophagy with FCCP, we developed a simple but acc...