Improvement on geometry and hemodynamics of coronary artery bypass grafting : numerical and experimental studies

Impaired local hemodynamics associated with unfavorable anastomotic geometry has been implicated in the initiation and progression of intimal hyperplasia and atherosclerosis, the two vascular diseases for failing bypass anastomoses. Focused on the distal coronary anastomosis, this thesis seeks to de...

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書目詳細資料
主要作者: Xiong, Fangli
其他作者: Chong Chuh Khiun
格式: Theses and Dissertations
出版: 2008
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在線閱讀:https://hdl.handle.net/10356/5424
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機構: Nanyang Technological University
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總結:Impaired local hemodynamics associated with unfavorable anastomotic geometry has been implicated in the initiation and progression of intimal hyperplasia and atherosclerosis, the two vascular diseases for failing bypass anastomoses. Focused on the distal coronary anastomosis, this thesis seeks to determine critical hemodynamic wall parameters that indicate disease-susceptible sites as well as to optimize anastomotic geometry and hemodynamics pertaining to long-term graft viability. Numerical simulation and in vitro experimentation using Particle Image Velocimetry were employed to study pulsatile flows in coronary anastomotic models.