Investigation of the correlation of magnetics resonance imaging based parameters and gait characteristics for diagnosis of sarcopenia.

Sarcopenia is defined as degenerative loss of skeletal muscle mass, strength and function with aging. Sarcopenia is first characterized by muscle atrophy along with a reduction in muscle tissue quality caused by factors such as replacement of muscle fibers with fat, an increase in fibrosis, changes...

Full description

Saved in:
Bibliographic Details
Main Author: Kumar Dilip.
Other Authors: Poh Chueh Loo
Format: Theses and Dissertations
Language:English
Published: 2013
Subjects:
Online Access:http://hdl.handle.net/10356/54298
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
Description
Summary:Sarcopenia is defined as degenerative loss of skeletal muscle mass, strength and function with aging. Sarcopenia is first characterized by muscle atrophy along with a reduction in muscle tissue quality caused by factors such as replacement of muscle fibers with fat, an increase in fibrosis, changes in muscle metabolism, oxidative stress, and degeneration of the neuromuscular junction. The several causes of sarcopenia are concomitance and can include disuse, changes in endocrine function, inflammation, chronic diseases, insulin resistance, and nutritional deficiencies. Combined, all these changes lead to progressive lower skeletal muscle mass, lower muscle strength, lower physical performance, thus resulting in reduced muscle function and frailty.