Investigation of the correlation of magnetics resonance imaging based parameters and gait characteristics for diagnosis of sarcopenia.

• Main Author: Kumar Dilip.
• Other Authors: Poh Chueh Loo
• Format: Theses and Dissertations
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Bioengineering
• Online Access: http://hdl.handle.net/10356/54298
• Institution: Nanyang Technological University

Sarcopenia is defined as degenerative loss of skeletal muscle mass, strength and function with aging. Sarcopenia is first characterized by muscle atrophy along with a reduction in muscle tissue quality caused by factors such as replacement of muscle fibers with fat, an increase in fibrosis, changes in muscle metabolism, oxidative stress, and degeneration of the neuromuscular junction. The several causes of sarcopenia are concomitance and can include disuse, changes in endocrine function, inflammation, chronic diseases, insulin resistance, and nutritional deficiencies. Combined, all these changes lead to progressive lower skeletal muscle mass, lower muscle strength, lower physical performance, thus resulting in reduced muscle function and frailty.