Structural features that affect β2 integrin expression and regulation of adhesion

• Main Author: Guan, Siyu
• Other Authors: Law Sai Kit, Alex
• Format: Theses and Dissertations
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/55003
• Institution: Nanyang Technological University

A hallmark for the Leukocyte Adhesion Deficiency 1 (LAD-1) syndrome is the defect in the β2 integrins due to mutations in the ITGB2 gene. To establish the correlation between LAD-1 genotype and phenotype, as well as better understand integrin function and structure, 19 LAD-1 missense mutants that re...